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Recombinant Human Interleukin-13/IL-13 Protein (Fc Tag)(Active)– MSE Supplies LLC

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Recombinant Human Interleukin-13/IL-13 Protein (Fc Tag)(Active)

SKU: PKSH032457-500

  • $ 3,90595



Recombinant Human Interleukin-13/IL-13 Protein (Fc Tag)(Active)

 

SKU # PKSH032457
Expression Host HEK293 Cells

 

 

Description

Synonyms ALRH, IL-13, IL13, P600
Species Human
Expression Host HEK293 Cells
Sequence Gly 21-Asn 132
Accession AAK53823.1
Calculated Molecular Weight 39.0 kDa
Observed Molecular Weight 50-55 kDa
Tag N-hFc
Bio-activity Immobilized recombinant human IL13RA2 at 8 μg/ml (100 μl/well) can bind IL13 with a linear range of 0.25-8.0 ng/ml.
  

 

Properties

Purity > 98 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4R&alpha;) and at least one of two known IL-13-specific binding chains (IL-13 R&alpha;1 and IL-13 R&alpha;2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.