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Recombinant Human Interleukin-21/IL-21 Protein (Active)
SKU: PKSH032631-50
Recombinant Human Interleukin-21/IL-21 Protein (Active)
| SKU # | PKSH032631 |
| Expression Host | E.coli |
Description
| Synonyms | CVID, Interleukin, IL21, CVID11, IL-21, Za11, Interleukin-21 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gln30-Ser162 |
| Accession | Q9HBE4 |
| Calculated Molecular Weight | 15.6 kDa |
| Observed Molecular Weight | 16 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL-21 induces the production of IgG1 and IgG3 in B-cells. IL-21 may promote the transition between innate and adaptive immunity. IL-21 may have a role in proliferation and maturation of natural killer cells in synergy with IL15. IL-21 stimulates interferon gamma production in T-cells and natural killer cells by synergy with IL15 and IL18. Dysregulation of IL-21 has a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases.