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Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG4 Fc)
SKU: PKSH032633-50
Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG4 Fc)
| SKU # | PKSH032633 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, IL-D, Interleukin, Cytokine Zcyto, TIFIL, zcyto, IL22, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, UNQ3099/PRO10096, UNQ3099, Interleukin-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, PRO10096, IL-D110, ILTIF, IL-TIF, TIFa, TIFIL-23, zcyto18 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala34-Ile179 |
| Accession | Q9GZX6 |
| Calculated Molecular Weight | 43.4 kDa |
| Observed Molecular Weight | 50-75 kDa |
| Tag | C-hIgG4 Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.