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Recombinant Human JAM-B/CD322 Protein (Fc Tag)
SKU: PKSH032663-50
Recombinant Human JAM-B/CD322 Protein (Fc Tag)
| SKU # | PKSH032663 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | C21orf43, CD322, JAM-2, JAM-B, JAM2, Junctional Adhesion Molecule 2, Junctional Adhesion Molecule B, VE-JAM, VEJAM, Vascular Endothelial Junction-Associated Molecule |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Phe29-Asn236 |
| Accession | P57087 |
| Calculated Molecular Weight | 50.4 kDa |
| Observed Molecular Weight | 60-75 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28); an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain; a transmembrane segment (aa 239-259); and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart; placenta; lung; foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.