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Recombinant Human LAG3/CD223 Protein (Fc Tag)(Active)
SKU: PKSH033597-50
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Recombinant Human LAG3/CD223 Protein (Fc Tag)(Active)
| SKU # | PKSH033597 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD223, LAG-3, LAG3, Lymphocyte activation gene 3 protein, Protein FDC |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu23-Leu450 |
| Accession | P18627 |
| Calculated Molecular Weight | 73.3 kDa |
| Observed Molecular Weight | 70-90 kDa |
| Tag | C-Fc |
| Bio-activity | Immobilized Anti-Human LAG-3 mAb at 2μg/ml (100 μl/well)can bind Human LAG-3-Fc. The ED50 of Human LAG-3-Fc is 6.76 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 10% Glycerol, 0.01% Tween20, 5% Trehalose, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.