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Recombinant Human LDLR Protein (His Tag/AVI)– MSE Supplies LLC

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Recombinant Human LDLR Protein (His Tag/AVI)

SKU: PKSH032711-100

  • $ 1,03595



Recombinant Human LDLR Protein (His Tag/AVI)

 

SKU # PKSH032711
Expression Host HEK293 Cells

 

 

Description

Synonyms FH, FHC, LDL R, LDL Receptor, LDLCQ2, LDLR, Low-Density Lipoprotein Receptor
Species Human
Expression Host HEK293 Cells
Sequence Ala22-Arg788
Accession P01130
Calculated Molecular Weight 88.4 kDa
Observed Molecular Weight 95-140 kDa
Tag C-Avi-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.