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Recombinant Human LILRB1 Protein (His Tag)
SKU: PDMH100016-100
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Recombinant Human LILRB1 Protein (His Tag)
| SKU # | PDMH100016 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD85 Antigen-Like Family Member J, CD85j, ILT-2, ILT2, Immunoglobulin-Like Transcript 2, LILRB1, LIR-1, Leukocyte Immunoglobulin-Like Receptor 1, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1, MIR-7, Monocyte/Macrophage Immunoglobulin-Like Receptor 7 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly24-His458 |
| Accession | D9IDM8 |
| Calculated Molecular Weight | 48.2 kDa |
| Observed Molecular Weight | 79 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
The immunoglobulin-like transcript (ILT) family (also named leukocyte Ig-like receptors (LIR) and monocyte/macrophage Ig-like receptors (MIR)) can be activating and inhibitory immunoreceptors. ILTs are expressed on many leukocyte subsets and regulators of immune responses . ILTs share significant homology with killer cell Ig-like receptors (KIR). Except ILT-6, all ILT family members are type I transmembrane proteins having two or four extracellular Ig-like domains . ILT2 is expressed on most monocytes,dendritic cells,and mature B cells. ILT2 is also expressed on small percentages of T-cells and NK cells. ILT2 can prevents cellular activation.