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Recombinant Human METAP1 Protein
SKU: PKSH033589-50
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Recombinant Human METAP1 Protein
| SKU # | PKSH033589 |
| Expression Host | E.coli |
Description
| Synonyms | MAP 1, MAP1A, METAP1, MetAP 1, MetAP1A, Methionine aminopeptidase 1, Peptidase M 1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Phe386 |
| Accession | P53582 |
| Calculated Molecular Weight | 43.2 kDa |
| Observed Molecular Weight | 38-50 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.