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Recombinant Human NCAM1 Protein (ECD, His Tag)
SKU: PKSH031994-100
Recombinant Human NCAM1 Protein (ECD, His Tag)
| SKU # | PKSH031994 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD56, CD56 antigen, MSK39, N-CAM-1, NCAM, NCAM-1, neural cell adhesion molecule, neural cell adhesion molecule 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Pro603 |
| Accession | NP_001070150.1 |
| Calculated Molecular Weight | 66.1 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
NCAM1, also known as CD56, is a neural adhesion protein (NCAM) which belongs to the immunoglobulin superfamily. NCAM is involved in neural development and in plasticity in the adult brain. UCHL1 is a novel interaction partner of both NCAM isoforms that regulates their ubiquitination and intracellular trafficking. NCAM1 is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. NCAM1 has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance.