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Recombinant Human NCR3/NKp30 Protein (His Tag)
SKU: PKSH032786-50
Recombinant Human NCR3/NKp30 Protein (His Tag)
| SKU # | PKSH032786 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 1C7, Activating Natural Killer Receptor p30, CD337, DAAP-90L16.3, LY117, MALS, NCR3, NK-p30, NKp30, Natural Cytotoxicity Triggering Receptor 3, Natural Killer Cell p30-Related Protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu19-Thr138 |
| Accession | O14931 |
| Calculated Molecular Weight | 12.8 kDa |
| Observed Molecular Weight | 19-33 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition; NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.