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Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active)
SKU: PKSH031590-100
Recombinant Human Nogo Receptor/NgR Protein (His & Fc Tag)(Active)
| SKU # | PKSH031590 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | NOGOR, NgR, Nogo Receptor, Nogo-66 Receptor, RTN4R, Reticulon-4 Receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser 447 |
| Accession | NP_075380.1 |
| Calculated Molecular Weight | 73.0 kDa |
| Observed Molecular Weight | 100 kDa |
| Tag | C-His-Fc |
| Bio-activity | Measured by its ability to bind recombinant human RTN4 in a functional ELISA. |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information |
Background
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.