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Recombinant Human NUDT5/ADP-sugar Pyrophosphatase Protein (His Tag)
SKU: PKSH030745-50
Recombinant Human NUDT5/ADP-sugar Pyrophosphatase Protein (His Tag)
| SKU # | PKSH030745 |
| Expression Host | E.coli |
Description
| Synonyms | YSA1, YSA1H, YSAH1, hYSAH1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Glu2-Phe219 |
| Accession | Q9UKK9 |
| Calculated Molecular Weight | 26.3 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
ADP-sugar Pyrophosphatase, also known as NUDT5, eliminates toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites. NUDT5 functions as a MutT-related protein and catalyzes the hydrolysis of 8-oxoGDP to 8-oxoGMP, thereby preventing misincorporation of 8-oxoGua into RNA. NUDT5 may play significant roles in regulating the G1-S transition in mammalian cells. It can also hydrolyze other nucleotide sugars with low activity.