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Recombinant Human P4HB Protein (His Tag)
SKU: PKSH033399-50
Recombinant Human P4HB Protein (His Tag)
| SKU # | PKSH033399 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Cellular Thyroid Hormone-Binding Protein, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, Prolyl 4-Hydroxylase Subunit Beta, Protein Disulfide-Isomerase, p55 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp18-Lys505 |
| Accession | P07237 |
| Calculated Molecular Weight | 55.9 kDa |
| Observed Molecular Weight | 65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.