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Recombinant Human Parvulin-14/PIN4 Protein (His Tag)
SKU: PKSH032859-50
Recombinant Human Parvulin-14/PIN4 Protein (His Tag)
| SKU # | PKSH032859 |
| Expression Host | E.coli |
Description
| Synonyms | PIN4, Parvulin-14, Parvulin-17, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, Peptidyl-prolyl cis-trans isomerase Pin4, Peptidyl-prolyl cis/trans isomerase EPVH, Rotamase Pin4 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys156 |
| Accession | Q9Y237-2 |
| Calculated Molecular Weight | 18.8 kDa |
| Observed Molecular Weight | 21 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.5. |
| Reconstitution | Not Applicable |
Background
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4(PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, PIN4 protein binds to double-stranded DNA under physiological salt conditions. PIN4 is involved as a ribosomal RNA processing factor in ribosome biogenesis. The PAR14 binds to tightly bent AT-rich stretches of double-stranded DNA, but PAR17 binds to double-stranded DNA.