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Recombinant Human PD-L1/B7-H1/CD274 Protein (Fc Tag)
SKU: PKSH032872-50
Recombinant Human PD-L1/B7-H1/CD274 Protein (Fc Tag)
| SKU # | PKSH032872 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | B7 Homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 Ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed Cell Death 1 Ligand 1, Programmed Death Ligand 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Phe19-Thr 239 |
| Accession | Q9NZQ7 |
| Calculated Molecular Weight | 52.4 kDa |
| Observed Molecular Weight | 70-80 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD274; also known as B7-H1 or programmed death ligand 1 (PD-L1); is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1; CD274; B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells; PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly; it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.