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Recombinant Human PDAP1/PAP Protein (His Tag)
SKU: PKSH032868-50
Recombinant Human PDAP1/PAP Protein (His Tag)
| SKU # | PKSH032868 |
| Expression Host | E.coli |
Description
| Synonyms | 28 kDa Heat- and Acid-Stable Phosphoprotein, HASPP28, PAP, PAP1, PDAP1, PDGF-Associated Protein, PDGFA-Associated Protein 1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys181 |
| Accession | Q13442 |
| Calculated Molecular Weight | 22.8 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 0.1mM PMSF, 2mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 show significantly less apoptosis on exposure to TNF-alpha.