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Recombinant Human PDCD4 protein (His Tag)
SKU: PDEH100038-100
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Recombinant Human PDCD4 protein (His Tag)
| SKU # | PDEH100038 |
| Expression Host | E. coli |
Description
| Synonyms | Death up-regulated gene protein;Dug;H731;Ma3;MGC33046;MGC33047;Neoplastic transformation inhibitor;Neoplastic transformation inhibitor protein;Nuclear antigen H731;Nuclear antigen H731 like;Nuclear antigen H731 like protein;Nuclear antigen H731-like;PDCD 4;Pdcd4;PDCD4;Programmed cell death 4;programmed cell death 4 (neoplastic transformation inhibitor);Programmed cell death protein 4;Protein 197/15a;Protein MA-3;Tis;Topoisomerase-inhibitor suppressed protein |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met1-Asn325 |
| Accession | Q53EL6 |
| Mol_Mass | 36.9 kDa |
| AP_Mol_Mass | 41-43 kDa |
| Tag | N-His |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.