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Recombinant Human PDGFRa/CD140a Protein (His Tag)
SKU: PKSH033564-50
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Recombinant Human PDGFRa/CD140a Protein (His Tag)
| SKU # | PKSH033564 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Alpha platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140A, PDGFR-2, PDGFR-alpha, PDGFR2, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor recepto, Platelet-derived growth factor receptor alpha, RHEPDGFRA |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln24-Glu524 |
| Accession | P16234 |
| Calculated Molecular Weight | 57.0 kDa |
| Observed Molecular Weight | 93 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Platelet-derived Growth Factor Receptor Alpha (PDGF Rα) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF Rα is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF Rα autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-γ pathways. PDGF Rα has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.