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Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)– MSE Supplies LLC

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Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

SKU: PKSH030653-50

  • $ 47295



Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

 

SKU # PKSH030653
Expression Host HEK293 Cells

 

Description

Synonyms Beta-Trace Protein, Cerebrin-28, Glutathione-Independent PGD Synthase, Lipocalin-Type Prostaglandin-D Synthase, PDS, PGD2 Synthase, PGDS, PGDS2, PTGDS, Prostaglandin D Synthase, Prostaglandin-D2 Synthase, Prostaglandin-H2 D-Isomerase
Species Human
Expression Host HEK293 Cells
Sequence Ala23-Gln190
Accession P41222
Calculated Molecular Weight 19.7 kDa
Observed Molecular Weight 20-27 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution Not Applicable


Background

Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.