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Recombinant Human PP2A-Cα/PPP2CA protein (His tag)
SKU: PDEH100357-100
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Recombinant Human PP2A-Cα/PPP2CA protein (His tag)
| SKU # | PDEH100357 |
| Expression Host | E. coli |
Description
| Synonyms | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PPP2CA; PP2A-alpha;Replication protein C (RP-C);PPP2CA |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met 1-Leu 309 |
| Accession | P67775 |
| Mol_Mass | 39.3 kDa |
| AP_Mol_Mass | 40 kDa |
| Tag | N-His & C-His |
| Bio_Activity | Not validated for activity |
Propertie
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Protein Phosphatase 2A (PP2A) is an enzyme that removes phosphates covalently attached to serine and threonine residues in proteins. It contains three subunits; a catalytic subunit C (PP2Ac), an assembly/structural subunit A (PP2Aa), and a regulatory subunit B (PP2Ab). PP2A is a ubiquitous enzyme that plays a role in regulating many cellular activities varying from ion transport in erythrocytes to suppressing tumor growth. Binding of the SV40 small T antigen to the PP2A phosphatase complex is known to cause oncogenic transformation.