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Recombinant Human Progonadoliberin-2/GNRH2 Protein (His Tag)
SKU: PKSH032936-50
Recombinant Human Progonadoliberin-2/GNRH2 Protein (His Tag)
| SKU # | PKSH032936 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GNRH2, GnRH II, GnRH-Associated Peptide 2, GnRH-Associated Peptide II, Gonadoliberin II, Gonadoliberin-2, Gonadotropin-Releasing Hormone II, LH-RH II, Luliberin II, Luteinizing Hormone-Releasing Hormone II, Progonadoliberin II, Progonadoliberin-2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln24-Val120 |
| Accession | O43555 |
| Calculated Molecular Weight | 11.6 kDa |
| Observed Molecular Weight | 14-25 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Progonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-fold). GNRH2 can be cleaved into two chains, gonadoliberin-2 and GnRH-associated peptide 2. gonadoliberin-2 regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. The proproteins produce three transcript variants, but produce the same peptide hormone.