Total Price: $0.00
Contact Information
Recombinant Human PSAP protein (His tag)
SKU: PDEH100138-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Human PSAP protein (His tag)
| SKU # | PDEH100138 |
| Expression Host | E. coli |
Description
| Synonyms | GLBA;SAP1p;PSAP;proactivator polypeptide;prosaposin; |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Gly 17-Asn 524 |
| Accession | P07602 |
| Mol_Mass | 55.8 kDa |
| AP_Mol_Mass | 45 kDa |
| Tag | N-His |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.