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Recombinant Human PSGL-1/CD162 Protein (His & Fc Tag)– MSE Supplies LLC

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Recombinant Human PSGL-1/CD162 Protein (His & Fc Tag)

SKU: PKSH031570-100

  • $ 65895



Recombinant Human PSGL-1/CD162 Protein (His & Fc Tag)

 

SKU # PKSH031570
Expression Host HEK293 Cells

 

 

Description

Synonyms CD162, CLA, P-selectin glycoprotein ligand 1, PSGL-1, PSGL1, SELPLG, Selectin P ligand
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Val295
Accession AAC50061.1
Calculated Molecular Weight 57.1 kDa
Observed Molecular Weight 110-120 kDa
Tag C-His-Fc
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~120 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.