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Recombinant Human PSPH Protein (His Tag)
SKU: PKSH032897-50
Recombinant Human PSPH Protein (His Tag)
| SKU # | PKSH032897 |
| Expression Host | E.coli |
Description
| Synonyms | L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSP, PSPH, PSPase, Phosphoserine Phosphatase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu225 |
| Accession | P78330 |
| Calculated Molecular Weight | 26.1 kDa |
| Observed Molecular Weight | 25-30 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 4M Urea, 5mM EDTA, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation; moderate psychomotor retardation and facial features suggestive of Williams syndrome.