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Recombinant Human QPRT/QPRTase Protein (His Tag)
SKU: PKSH032985-50
Recombinant Human QPRT/QPRTase Protein (His Tag)
| SKU # | PKSH032985 |
| Expression Host | E.coli |
Description
| Synonyms | Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating], QAPRTase, QPRT, QPRTase, Quinolinate Phosphoribosyltransferase [Decarboxylating] |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-His297 |
| Accession | AAH05060.1 |
| Calculated Molecular Weight | 33.0 kDa |
| Observed Molecular Weight | 34 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.