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Recombinant Human RANK/TNFRSF11A Protein (His Tag)
SKU: PKSH032987-50
Recombinant Human RANK/TNFRSF11A Protein (His Tag)
| SKU # | PKSH032987 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD265, CD265 antigen, FEO, ODFR, ODFROSTS, OFE, OPTB7, PDB2, RANK1, Receptor activator of NF-KB, TNFRSF11A, TRANCE R, TRANCER, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily member 11A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ile30-Pro212 |
| Accession | Q9Y6Q6 |
| Calculated Molecular Weight | 21.1 kDa |
| Observed Molecular Weight | 25-30 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.