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Recombinant Human S100A8 Protein (His Tag)
SKU: PKSH033008-50
Recombinant Human S100A8 Protein (His Tag)
| SKU # | PKSH033008 |
| Expression Host | E.coli |
Description
| Synonyms | 60B8AG, CAGA, CFAG, CGLA, CP-10, Calgranulin-A, Cystic fibrosis antigen, L1Ag, Leukocyte L1 complex light chain, MA387, MIF, MRP-8, MRP8, NIF, P8, Protein S100-A8, S100A8 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu93 |
| Accession | P05109 |
| Calculated Molecular Weight | 11.7 kDa |
| Observed Molecular Weight | 13 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 150mM NaCl, 20% Glycerol, 2mM EDTA, 0.05% Tween 80, pH8.5 |
| Reconstitution | Not Applicable |
Background
Protein S100-A8 (also MRP8 and calgranulin A) is a calcium- and zinc-binding protein.It plays a prominent role in the regulation of inflammatory processes and immune response. S100A8 can induce neutrophil chemotaxis and adhesion. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. It can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.