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Recombinant Human Sedoheptulokinase/SHPK Protein (His Tag)
SKU: PKSH033014-50
Recombinant Human Sedoheptulokinase/SHPK Protein (His Tag)
| SKU # | PKSH033014 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CARKL, Carbohydrate kinase-like protein, SHK, SHPK, Sedoheptulokinase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser478 |
| Accession | AAH20543.1 |
| Calculated Molecular Weight | 52.5 kDa |
| Observed Molecular Weight | 53 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 3mM DTT, pH7.4. |
| Reconstitution | Not Applicable |
Background
Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very weakly expressed in lung and brain. SHPK catalyzes the chemical reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphatecan, It can transform sedoheptulose to sedoheptulose 7-phosphate in the condition of ATP, and acts as a modulator of macrophage activation through control of glucose metabolism. In addition, It also can be down-regulated by LPS.