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Recombinant Human SEMA4B Protein (His Tag)
SKU: PKSH033020-50
Recombinant Human SEMA4B Protein (His Tag)
| SKU # | PKSH033020 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | KIAA1745, SEMAC and SEMA4B, Semaphorin-4B |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu39-Glu712 |
| Accession | Q9NPR2 |
| Calculated Molecular Weight | 75.7 kDa |
| Observed Molecular Weight | 86 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B is a single-pass type I membrane protein and contains one Ig-like C2-type (immunoglobulin-like) domain; one PSI domain and one Sema domain. Human SEMA4B is expressed in neurons. SEMA4B inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. SEMA4B negatively regulates basophil-mediated Th2 and humoral memory responses.