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Recombinant Human Semaphorin 4D/SEMA4D Protein (Fc Tag)(Active)
SKU: PKSH033023-50
Recombinant Human Semaphorin 4D/SEMA4D Protein (Fc Tag)(Active)
| SKU # | PKSH033023 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | A8, BB18, C9orf164, CD100, GR3, M-sema-G, SEMAJ, Semaphorin-4D, coll-4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met22-Arg734 |
| Accession | AAH54500.1 |
| Calculated Molecular Weight | 106.4 kDa |
| Observed Molecular Weight | 130-170 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Semaphorin-4D is also known as A8;BB18; GR3; CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain; 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells; regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/PYK2; which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.