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Recombinant Human Semenogelin-1/SEMG1 Protein (His Tag)
SKU: PKSH033025-50
Recombinant Human Semenogelin-1/SEMG1 Protein (His Tag)
| SKU # | PKSH033025 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Alpha-Inhibin-31, Alpha-Inhibin-92, SEMG, SEMG1, SGI, Semenogelin I, Semenogelin-1, Seminal Basic Protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln24-Thr402 |
| Accession | AAH07096.1 |
| Calculated Molecular Weight | 43.8 kDa |
| Observed Molecular Weight | 25-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Hac-NaAc, 150mM NaCl, pH 4.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Semenogelin-1 (SEMG1) is the predominant protein in semen; it is a secretory protein involved in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes SEMG1 into smaller peptides, each possibly having a separate function. In the proteolysis process, Alpha-inhibin-92 and alpha-inhibin-31 are produced; they inhibit the secretion of pituitary follicle-stimulating hormone. At the same time, it breaks down the gel matrix, allowing the spermatozoa to move more freely.