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Recombinant Human SENP2 Protein (His Tag, SUMO Tag)
SKU: PKSH033026-50
Recombinant Human SENP2 Protein (His Tag, SUMO Tag)
| SKU # | PKSH033026 |
| Expression Host | E.coli |
Description
| Synonyms | Axam2, KIAA1331, SENP2. , SMT3-specific isopeptidase 2, Sentrin-specific protease 2, Sentrin/SUMO-specific protease SENP2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Asp363-Leu589 |
| Accession | Q9HC62 |
| Calculated Molecular Weight | 26.8 kDa |
| Observed Molecular Weight | 29 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM HEPES,5% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. It has been implicated as a down-regulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway.