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Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)
SKU: PKSH032695-50
Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)
| SKU # | PKSH032695 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | EI, ELANH2, HEL-S-27, HEL57, LEI, Leukocyte elastase inhibitor, M/NEI, MNEI, Monocyte/neutrophil elastase inhibitor, PI-2, PI2, Peptidase inhibitor 2, SERPINB1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Pro379 |
| Accession | P30740 |
| Calculated Molecular Weight | 43.8 kDa |
| Observed Molecular Weight | 40-56 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
SERPINB1 is a member of the serpin family and Ov-serpin subfamily. As protease inhibitors; serpins have an array of functions including regulating blood coagulation; fibrinolysis; the complement pathway; angiogenesis; inflammation; tumor suppression; extracellular matrix remodeling; and cell motility. SERPINB1 regulates the activity of the neutrophil proteases elastase; cathepsin G; proteinase-3; chymase; chymotrypsin; and kallikrein-3. Reactive bond 1 of SerpinB1 is specific for reaction with chymotrypsin-like protease such as cathepsin G; chymotrypsin or chymase. Reactive bond 2 of SerpinB1 is specific for reaction with elastase-like protease such as neutrophyl elastase; proteinase-3; pancreatic elastase or PSA. In addition; SERPINB1 also functions as a potent intracellular inhibitor of granzyme H.