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Recombinant Human SerpinI2 Protein (His Tag)
SKU: PKSH033045-50
Recombinant Human SerpinI2 Protein (His Tag)
| SKU # | PKSH033045 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | MEPI, Myoepithelium-derived serine protease inhibitor, PANCPIN, PI-14, PI14, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, SERPINI2, Serpin I2, TSA2004 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser19-Leu405 |
| Accession | O75830 |
| Calculated Molecular Weight | 45.1 kDa |
| Observed Molecular Weight | 44-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
SERPINI2 is a secreted protein of the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. As protease inhibitors, serpins have an array of functions including regulating blood coagulation, fibrinolysis, the complement pathway, angiogenesis, inflammation, tumor suppression, extracellular matrix remodeling, and cell motility. SERPINI2 is expressed in human tissues including pancreas and adipose tissues. Mutations of human SERPINI2 can directly result in conditions such as acinar cell apoptosis and malabsorption.