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Recombinant Human Sialidase-1/NEU-1 Protein (His Tag)
SKU: PKSH033056-50
Recombinant Human Sialidase-1/NEU-1 Protein (His Tag)
| SKU # | PKSH033056 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Acetylneuraminyl Hydrolase, G9 Sialidase, Lysosomal Sialidase, N-Acetyl-Alpha-Neuraminidase 1, NANH, NEU1, Sialidase-1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu48-Leu415 |
| Accession | Q99519 |
| Calculated Molecular Weight | 41.3 kDa |
| Observed Molecular Weight | 39-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.