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Recombinant Human SLAM Family Member 7/SLAMF7/CD319/CRACC (C-mFc)
SKU: PKSH033992-50
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Recombinant Human SLAM Family Member 7/SLAMF7/CD319/CRACC (C-mFc)
| SKU # | PKSH033992 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, PRO, SLAM, SLAMF7, 19A, CD319, CRACC, CS1, 19A24 protein, CD 319, CD2 like receptor activating cytotoxic cells, CD2 subset 1, CD2-Like Receptor-Activating Cytotoxic Cells, CD319 antigen, Membrane protein FOAP 12, Membrane Protein FOAP-12, Novel Ly9, Novel LY9 (lymphocyte antigen 9) like protein, Protein 19A, SLAM family member 7, SLAM7, SLAMF 7, UNQ576, PRO1138, CS1, CD319, CRACC, CS1, Novel Ly9 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser23-Met226 |
| Accession | Q9NQ25 |
| Calculated Molecular Weight | 49.0 kDa |
| Observed Molecular Weight | 60-90 kDa |
| Tag | C-mFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.