Total Price: $0.00
Contact Information
Recombinant Human SOCS2 protein (His tag)
SKU: PDEH100325-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Human SOCS2 protein (His tag)
| SKU # | PDEH100325 |
| Expression Host | E. coli |
Description
| Synonyms | Suppressor of cytokine signaling 2;SOCS2;Cytokine-inducible SH2 protein 2;STAT-induced STAT inhibitor 2 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met 1-Val 198 |
| Accession | O14508 |
| Mol_Mass | 21.7 kDa |
| AP_Mol_Mass | 25 kDa |
| Tag | N-His & C-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
SOCS-2 (Suppressor of cytokine signaling 2; also CIS-2 and SSI-2) is a 25 kDa member of the SOCS family of proteins. It is an SH2-domain containing cytoplasmic adaptor protein expressed by multiple cell types. It blocks receptor signaling by binding to phosphorylated tyrosines in the cytoplasmic domain of select receptors, including the receptors for leptin, IGF-I and GH. Human SOCS-2 is 198 amino acids (aa) in length and contains one SH2 domain (aa 48?156) and a SOCS box (aa 160?198) that mediates interaction with elongin B or C of the E3 ubiquitin ligase complex. There is one splice variant that shows an Arg-rich eight aa substitution for aa 31?39. Full-length SOCS-2 is 94% and 96% aa identical to mouse and porcine SOCS-2, respectively.