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Recombinant Human SorCS1 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human SorCS1 Protein (His Tag)

SKU: PKSH030959-100

  • $ 65895



Recombinant Human SorCS1 Protein (His Tag)

 

SKU # PKSH030959
Expression Host HEK293 Cells

 

Description

Synonyms RP11-446H13.1, hSorCS
Species Human
Expression Host HEK293 Cells
Sequence Ser 111-Ser 1099
Accession Q8WY21-1
Calculated Molecular Weight 113 kDa
Observed Molecular Weight 130 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 92 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

VPS10 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein which belongs to theSORCS family and SORCS1 subfamily. SORCS1 contains fiveBNR repeats and onePKD domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and signal transduction. The individual receptors bind and internalize a variety of ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal expression, several of the identified ligands, and results support the notion that members of this receptor family have important functions in neurogenesis, plasticity-related processes, and functional maintenance of the nervous system. Sortilin and SorLA mediate intracellular protein trafficking and sorting. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms differing only in their cytoplasmic domains. SorCS1 binds platelet-derived growth factor, a growth factor crucial for pericyte recruitment to the microvasculature, and may thus have a role in expanding or maintaining the islet vasculature.