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Recombinant Human SPOCK1/Testican 1 Protein (aa 21-429, His Tag)– MSE Supplies LLC

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Recombinant Human SPOCK1/Testican 1 Protein (aa 21-429, His Tag)

SKU: PKSH031498-50

  • $ 40895



Recombinant Human SPOCK1/Testican 1 Protein (aa 21-429, His Tag)

 

SKU # PKSH031498
Expression Host Baculovirus-Insect Cells

 

 

Description

Synonyms SPOCK, TESTICAN, TIC1
Species Human
Expression Host Baculovirus-Insect Cells
Sequence Met 1-Trp439
Accession Q08629
Calculated Molecular Weight 48.4 kDa
Observed Molecular Weight 53 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Osteonectin, also known as SPOCK1, is an extracellular heparan/chondroitin sulfate proteoglycan. Members of this family are known as testicans, also called SPOCKs. They are characterized structurally by an N-terminal testican-specific domain, a follistatin-like region, a calcium-binding domain, a thyroglobulin-like domain, and an acidic C-terminal domain with two putative glycosaminoglycan attachment sites. SPOCKs are enriched in brain and have been shown to regulate neuronal attachment and outgrowth. They contain inhibitory regions in several domains targeted to different classes of protease, and in some cases may act as protease inhibitors. Osteonectin contains 1 Kazal-like domain and 1 thyroglobulin type-1 domain. Up to now, little is known about osteonectin’s function. It may play a role in cell-cell and cell-matrix interactions. Osteonectin also may contribute to various neuronal mechanisms in the central nervous system.