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Recombinant Human SULT1A1 Protein (His Tag)
SKU: PKSH033358-50
Recombinant Human SULT1A1 Protein (His Tag)
| SKU # | PKSH033358 |
| Expression Host | E.coli |
Description
| Synonyms | Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, P-PST 1, Phenol Sulfotransferase 1, Phenol-Sulfating Phenol Sulfotransferase 1, ST1A1, ST1A3, STP, STP1, SULT1A1, Sulfotransferase 1A1, Thermostable Phenol Sulfotransferase, Ts-PST |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Leu295 |
| Accession | AAH00923.1 |
| Calculated Molecular Weight | 35.6 kDa |
| Observed Molecular Weight | 32 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 50mM Nacl, 0.05% Tween 80, pH7.8. |
| Reconstitution | Not Applicable |
Background
Sulfotransferase 1A1 (SULT1A1) is a cytosolic sulfotransferases that is expressed in the liver; lung; adrenal; brain; platelets; and skin. SULT1A1 is a phenol sulfotransferases with thermostable enzyme activity. SULT1A1 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines; phenolic drugs and neurotransmitters. It is responsible for the sulfonation and activation of minoxidil. SULT1A1 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.