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Recombinant Human TCblR/8D6A Protein (Fc Tag)
SKU: PKSH033134-50
Recombinant Human TCblR/8D6A Protein (Fc Tag)
| SKU # | PKSH033134 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 8D6 antigen, CD320, CD320 antigen, FDC-SM-8D6, FDC-signaling molecule 8D6, TCblR, Transcobalamin receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser36-Val231 |
| Accession | Q9NPF0 |
| Calculated Molecular Weight | 47.3 kDa |
| Observed Molecular Weight | 58-60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD320 antigen is also known as 8D6 antigen,FDC-signaling molecule 8D6,Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. CD320 can augments the proliferation of plasma cells precursors generated by IL-10. CD320 also founctions a receptor for the cellular uptake of transcobalamin bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC) which is a metabolic disorder.