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Recombinant Human THOP1 Protein (His Tag)
SKU: PKSH033105-50
Recombinant Human THOP1 Protein (His Tag)
| SKU # | PKSH033105 |
| Expression Host | E.coli |
Description
| Synonyms | Endopeptidase 24.15, MP78, THOP1, Thimet Oligopeptidase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Lys2-Cys689 |
| Accession | P52888 |
| Calculated Molecular Weight | 80.0 kDa |
| Observed Molecular Weight | 85 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 50% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.