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Recombinant Human Tie2/CD202b Protein (His & Fc Tag)(Active)– MSE Supplies LLC

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Recombinant Human Tie2/CD202b Protein (His & Fc Tag)(Active)

SKU: PKSH031473-200

  • $ 65895



Recombinant Human Tie2/CD202b Protein (His & Fc Tag)(Active)

 

SKU # PKSH031473
Expression Host HEK293 Cells

 

 

Description

Synonyms CD202B, TIE-2, TIE2, VMCM, VMCM1
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Lys 745
Accession NP_000450.2
Calculated Molecular Weight 108.5 kDa
Observed Molecular Weight 125-135 kDa
Tag C-His-Fc
Bio-activity Immobilized recombinant human Angiopoietin-2 at 10 μg/ml (100 μl/well) can bind Human Tie2 / Fc chimera with a range of 0.2-20 μg/ml.
  

 

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. vasculature.