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Recombinant Human TNFSF4/OX40L Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human TNFSF4/OX40L Protein (His Tag)(Active)

SKU: PKSH032842-50

  • $ 47095



Recombinant Human TNFSF4/OX40L Protein (His Tag)(Active)

 

SKU # PKSH032842
Expression Host HEK293 Cells

 

 

Description

Synonyms CD134L, CD252, GP34, Glycoprotein Gp34, OX-40, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, TNFSF4, TXGP1, Tumor necrosis factor ligand superfamily member 4
Species Human
Expression Host HEK293 Cells
Sequence Gln51-Leu183
Accession P23510
Calculated Molecular Weight 16.3 kDa
Observed Molecular Weight 20-30 kDa
Tag N-His
Bio-activity Loaded Biotinylated Human OX40L-His on AR2G Biosensor, can bind Human OX40-Fc with an affinity constant of 70.3 nM as determined in BLI assay. 
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells; T cells; dendritic cells and endothelial cells. OX40L binds to OX40 (CD134); a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional; it has been found association with systemic lupus erythematosus; no association with occurrence of atherosclerosis.