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Recombinant Human Tryptase β-2/TPSB2 Protein (His Tag)
SKU: PKSH033154-50
Recombinant Human Tryptase β-2/TPSB2 Protein (His Tag)
| SKU # | PKSH033154 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | TPS2, TPSB2, Tryptase Beta-2, Tryptase II, Tryptase-2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala19-Pro275 |
| Accession | AAH29356.1 |
| Calculated Molecular Weight | 29.6 kDa |
| Observed Molecular Weight | 30-35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.