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Recombinant Human VCP Protein (His Tag)
SKU: PKSH033203-50
Recombinant Human VCP Protein (His Tag)
| SKU # | PKSH033203 |
| Expression Host | E.coli |
Description
| Synonyms | 15S Mg(2+)-ATPase p97 Subunit, TER ATPase, Transitional Endoplasmic Reticulum ATPase, VCP, Valosin-Containing Protein |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala2-Asn589 |
| Accession | P55072 |
| Calculated Molecular Weight | 66.3 kDa |
| Observed Molecular Weight | 75 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, pH8.0. |
| Reconstitution | Not Applicable |
Background
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.