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Recombinant Human VWFCP/ADAMTS13 protein (His tag)
SKU: PDEH100232-100
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Recombinant Human VWFCP/ADAMTS13 protein (His tag)
| SKU # | PDEH100232 |
| Expression Host | E. coli |
Description
| Synonyms | ADAM-TS 13;ADAMTS 13;ATS13;C9orf8;TTP;Von Willebrand factor cleaving protease;vWF CP;vWF-cleaving protease |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Thr 1151-Thr 1427 |
| Accession | Q76LX8 |
| Mol_Mass | 30.4 kDa |
| AP_Mol_Mass | 31 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.Zinc and calcium ions cooperatively modulate enzyme activity. The cleavage of the pro-domain is not required for protease activity. Dependence on calcium for proteolytic activity is mediated by the high affinity site.