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Recombinant Rat IL-6 Protein
SKU: PDMR100004-100
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Recombinant Rat IL-6 Protein
| SKU # | PDMR100004 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Interleukin, B-cell growth factor, B-cell stimulatory factor, Lymphocyte stimulatory factor, BCGF1, B-cell IGG differentiation factor, B-cell stimulatory factor 1, BCGF-1, Binetrakin, BSF1, Interleukin-4, Lymphocyte stimulatory factor 1, Pitrakinra, Il4, BSF-1, Lymphocy, Il 4, B-cell growth factor 1, Il-4, IL4、BCGF-1、BCGF1、BSF-1、BSF1 |
| Species | Rat |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Ser147 |
| Accession | P20096 |
| Calculated Molecular Weight | 16.5 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4., 5% trehalose, 5% mannitol, 0.01% Tween 80. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
Background
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.