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Recombinant Rat Lamin B1 Protein (His Tag)
SKU: PDER100009-100
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Recombinant Rat Lamin B1 Protein (His Tag)
| SKU # | PDER100009 |
| Expression Host | E. coli |
Description
| Synonyms | ADLD, LMN, LMN2, LMNB, LMNB1, Lamin-B1, Lmnb1, MGC111419, OTTHUMP00000159218, lamin B1 |
| Species | Rat |
| Expression Host | E.coli |
| Sequence | Arg387-Met587 |
| Accession | P70615-1 |
| Calculated Molecular Weight | 22.1 kDa |
| Observed Molecular Weight | 25.4 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).