MSE PRO 1-Boc-2-methyl-DL-proline, ≥95.0% Purity

MSE PRO™ 1-Boc-2-methyl-DL-proline, ≥95.0% Purity

MSE PRO™ 1-Boc-2-methyl-DL-proline is a versatile and valuable synthetic building block for organic synthesis and medicinal chemistry applications. As a proline derivative, it possesses a unique rigid pyrrolidine ring structure that can impart conformational constraints and influence the biological activity of target molecules. The presence of the tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection under mild acidic conditions, revealing a reactive secondary amine functionality. This feature enables further derivatization and the controlled introduction of diverse substituents, facilitating the synthesis of complex peptidomimetics, heterocyclic compounds, and potential drug candidates.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

References:

[1] Boss, C., Gatfield, J., Brotschi, C., Heidmann, B., Sifferlen, T., von Raumer, M., ... & Roch, C. (2020). The quest for the best dual orexin receptor antagonist (daridorexant) for the treatment of insomnia disorders. ChemMedChem, 15(23), 2286-2305.

[2] Hennecke, U., Guria, S., Volkov, A. N., Khudaverdyan, R., Van Lommel, R., Daniliuc, C. G., & De Proft, F. (2023). Enantioselective Synthesis of Pyrrolidines by Imidodiphosphorimidate (IDPi)-catalysed anti-hydroamination of alkenes.